On-chain metrics and impact on short-term moves

I'm still getting my head around how the various on-chain metrics actually translate into actionable insights for shorter-term trades on $BTC. I see people referencing SOPR or MVRV, for example, and the general idea makes sense for macro bottoms/tops, but how do you integrate these into a more swing-trading timeframe? Is it more of a confirmation signal for your existing technical analysis, or do some of you use specific on-chain shifts as a primary trigger for entries/exits on a weekly or daily chart? My concern is that by the time a clear signal from these long-term indicators appears, a significant portion of the move has already happened on the lower timeframes. How do others here reconcile that lag?