KYB for non-US entities operating within the US crypto space - any real-world experiences?

We're a non-US entity looking to onboard some institutional clients from the US for our crypto derivatives platform. Specifically, I'm trying to nail down best practices for KYB when the entity itself is non-US, but they're dealing with US-based funds or beneficial owners. The regulatory landscape here is a minefield. Are you seeing specific pain points with the interagency guidance, especially around OFAC and SAR reporting thresholds when a foreign institution is involved, but the ultimate beneficiaries might be US persons? It's less about the technical KYC/B process and more about what's actually being flagged and scrutinized in practice.